Pipeline        Macimorelin         AGHD          CGHD

Adult Growth Hormone Deficiency (AGHD)

Growth hormone (GH) is critical to Lifelong Health

Maintains Normal Body Stature and Regulates Metabolism

No single signs or symptoms, but recognized by:

• Metabolic syndrome

• Osteoporosis

• Muscle wasting

• Low physical/mental energy

• Impaired quality of life

Increased risk of:

• Cardiovascular (CV) issues

• Bone fractures

Growth hormone not only plays an important role in growth from childhood to adulthood, but also helps promote a hormonally balanced health status. AGHD most commonly results from damage to the pituitary gland. It is usually characterized by a reduction in bone mineral density, lean body mass, exercise capacity, and overall quality of life as well as an increase of cardiovascular risks.

 

AGHD may occur in an adult subject who has a history of childhood-onset growth hormone deficiency (CGHD) or may occur during adulthood as an acquired condition.

Number of Potential Tests Annually

28,000-62,000*

14,000-28,000*

*Navigant study 2009, TVG study 2017, Huron Consulting study 2018

In other areas of the world, the incidence and prevalence of AGHD are not known, and awareness and diagnosis remain low. GH not only plays an important role in growth from childhood to adulthood, but also helps promote a hormonally balanced health status. AGHD mostly results from damage to the pituitary gland, which can be caused by tumors, traumatic brain injury, brain infarction, radiation, or infections. It is usually characterized by a reduction in bone mineral density, lean body mass, exercise capacity, and overall quality of life as well as an increased cardiovascular risk profile.

Adult Test Procedure  (Macimorelin)

No Physician Supervision Required

 

Nurse Administered

Fasted Patient

(at least 8 hours)

Patient Drinks Solution

1 ml (0.5 mg/kg)

per kg body weight

FDA

EMA

30

45

60

90

45

60

90

-

Blood Draws

(minutes)

©2020 Aeterna Zentaris  All rights reserved.
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