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Pipeline        AIM Biologicals         AEZS-150        AEZS-130 (Macimorelin)        Macimorelin Dx         Publications        

AEZS-150 (Delayed Clearance Parathyroid Hormone Fusion Polypeptides DC-PTH)

 Treatment of Chronic Hypoparathyroidism

AEZS-150 (DC-PTH) is the active part of the parathyroid hormone, PTH1-34, linked to a modified version of the growth hormone binding protein (GHBP) with the goal of replacing the PTH activity for one week.

We envision self-administered weekly injections of AEZS-150 to maintain normal serum calcium, phosphate levels, and urinary calcium secretion in patients with hypoparathyroidism. 


Affects ~23-37 in every 
people in
the US and E

Results in Renal dysfunction; Muscle cramping; Twitching; Seizures; Cardiac arrhythmias 

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